Investigating the contribution of mulberry leaf Fu tea to ameliorating metabolic disorders and remodeling gut microbiota in diabetic mice
نویسندگان
چکیده
Dysbiosis of the gut microbiota and metabolic disorders contributes to occurrence diabetes mellitus. Polyphenols reduce risk type II mellitus (T2DM) by inhibiting α-glucosidase. Mulberry leaf Fu tea (FM) is a kind obtained fermentation Eurotium cristatum, which polyphenol-enriched has distinctive aroma, but its antidiabetic mechanism unclear. In this study, we investigated polyphenols in aqueous extract FM through HRLC-MS verified inhibitory effect on α-glucosidase vitro test finally studied short-chain fatty acids (SCFAs) diabetic mice. The findings demonstrated that supplementation considerably altered abnormalities mice, maintained balance microflora, encouraged growth beneficial microorganisms (Coriobacteriaceae UCG-002, Dubosiella, Lactobacillus, Bifidobacterium), increased levels acetic acid, propionic butyric acid. conclusion, can regulate SCFAs ameliorate or alleviate T2DM caused HFD-STZ. Therefore, also be used as postbiotics improve T2DM.
منابع مشابه
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ژورنال
عنوان ژورنال: Food frontiers
سال: 2023
ISSN: ['2643-8429']
DOI: https://doi.org/10.1002/fft2.294